The oldest building on Semakov Street is the Znamensky Cathedral. Almost every house on Semakov Street was a monument:
- Memorial plaque to S. O. Makarov at house No. 1. During a trip to Western Siberia on September 12−14, 1897, Russian naval officer, oceanographer, Vice Admiral Stepan Osipovich Makarov (1848−1904) stayed in this house.
- Memorial plaque to V. L. Khudyakov at 8a. The building of the former secondary school No. 1, where Viktor Leonidovich Khudyakov (1923−1945), Hero of the Soviet Union, studied.
- Memorial plaque on house No. 17. This building housed a hospital for wounded soldiers of the Soviet Army during the Great Patriotic War of 1941−1945.
- Memorial plaque on house No. 8. The House of the Chiralov merchants is a monument of history and culture of regional importance in the second half of the 19th century.
- Memorial plaque at house No. 36. The house is of architectural and artistic value. Built at the end of the 19th century, it belonged to the merchant of the 1st guild, the hereditary honorary citizen of Tyumen P. I. Podaruyev.
- Memorial plaque at house No. 31. The house of M. S. Seliverstov in 1908.